As the Raman scattering is inherently low and not useful for low-concentrated samples, the SERS technique is being widely employed for different applications. This technique is based on the enhancement of Raman signals by the interaction between molecules and metallic surfaces. Metal screen-printed electrodes are promising SERS substrates because they are available in different materials such as gold, silver, or metal nanoparticles… They are readily available, cost-effective, disposable, and only need a low sample volume. Some of the recommended SPEs could be C013 model with silver WE or 220BT with low temperature curing gold.